Altered Gut Microbiome Composition and Function in Individuals with Complex Regional Pain Syndrome.

Journal: Anesthesiology
Published Date: Mar 5, 2025

Abstract

BACKGROUND: Complex regional pain syndrome is a chronic pain syndrome typically affecting a limb. It is characterized by severe spontaneous and evoked pain, along with vasomotor, autonomic, and motor signs and symptoms. Although dysregulation in several physiologic systems has been suggested in complex regional pain syndrome (CRPS), including aberrant inflammatory and immune responses, vasomotor dysfunction, and nervous system changes, the pathophysiologic mechanisms underlying the syndrome remain elusive. Effective treatment options are also limited. Previous research has highlighted the role of the gut microbiome in chronic pain, prompting us to investigate the composition and function of the gut microbiome in CRPS.

Authors

  • Emmanuel Gonzalez
    McGill Centre for Microbiome Research, McGill University, Montreal, Quebec, Canada; Canadian Center for Computational Genomics, McGill University and Genome Quebec Innovation Center, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  • Tali Sahar
    Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.
  • May Haddad
    Rambam Health Campus, Haifa, Israel; Ruth and Bruce Rapaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
  • Sylvie Toupin
    Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.
  • Ramzi Zioud
    Department of Anesthesia and Operating Rooms, Galilee Medical Center, Nahariya, Israel.
  • Muhammad Zoabi
    Ruth and Bruce Rapaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
  • Lilach Eyal Waldman
    Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.
  • Zohar Tal Leshinsky
    Rambam Health Campus, Haifa, Israel.
  • Maayan Ben Sasson
    Institute for Pain Medicine, Rambam Health Campus, Haifa, Israel. maayanbensasson@gmail.com.
  • Vibhu Kumar
    Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.
  • Yosefa Marom
    Rambam Health Campus, Haifa, Israel.
  • Ayelet Midbari
    Pain Relief Unit, Hillel Yaffe Medical Center, Hadera, Israel.
  • Nicholas J B Brereton
    School of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
  • Yoram Shir
    Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.
  • Amir Minerbi
    Rambam Health Campus, Haifa, Israel; Ruth and Bruce Rapaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel; Clinical Research Institute at Rambam, Haifa, Israel.

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