Gut microbiome alterations and hepatic encephalopathy post-TIPS in liver cirrhosis patients.

Journal: Journal of translational medicine
Published Date: Jul 4, 2025

Abstract

BACKGROUND: The transjugular intrahepatic portosystemic shunt (TIPS), a crucial tool for treating complications related to portal hypertension in patients with liver cirrhosis, is often associated with an increased risk of postoperative complications such as hepatic encephalopathy. Accurate preoperative prediction of the risk of developing hepatic encephalopathy is critical for optimizing the rational clinical application of TIPS.

Authors

  • Shengpeng Li
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • Zhengguo Xu
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • Hua Diao
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • An Zhou
    BGI-Shenzhen, Shenzhen, Guangdong, 518083, China.
  • Dianji Tu
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • Sumin Wang
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • Yunxuan Feng
    Department of Gastroenterology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
  • Xiaojie Feng
    School of Public Health, Xi'an Jiaotong University, Xi'an, China.
  • Yi Lai
    School of Communications and Information Engineering, Xi'an University of Posts and Telecommunications, Xi'an, China.
  • Shiming Yang
    University of Maryland School of Medicine, Baltimore, MD 21201, United States.
  • Bo Tang
    Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, 45 Upper College Rd., Kingston, RI, 02881, USA.

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