The unwell patient with advanced chronic liver disease: when to use each score?

Journal: BMC medicine
Published Date: Jul 9, 2025

Abstract

BACKGROUND: Prognostication in chronic liver disease and the implementation of appropriate scoring systems is difficult given the variety of clinical manifestations. It is important to understand the limitations of each scoring system as well as the context and patient group from which it was developed to allow appropriate application. This review seeks to explore the optimal clinical uses of different predictive scores developed for compensated and decompensated chronic liver disease, acute on chronic liver failure, and hepatocellular carcinoma. We will also review future areas of research for each score and current gaps in the literature.

Authors

  • Oliver Moore
    Blacktown Clinical School, School of Medicine, Western Sydney University, Blacktown, NSW, Australia.
  • Wai-See Ma
    Blacktown Clinical School, School of Medicine, Western Sydney University, Blacktown, NSW, Australia.
  • Scott Read
    Blacktown Clinical School, School of Medicine, Western Sydney University, Blacktown, NSW, Australia.
  • Jacob George
    Department of Nephrology, Medical College, Thiruvananthapuram, Kerala, India.
  • Golo Ahlenstiel
    Blacktown Clinical School, School of Medicine, Western Sydney University, Blacktown, NSW, Australia. g.ahlenstiel@westernsydney.edu.au.

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