Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment.

Journal: BMC geriatrics
Published Date:

Abstract

BACKGROUND: Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function.

Authors

  • Carly Welch
    Department of Twin Research & Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, 3rd Floor South Wing D Block, St Thomas' Campus, Westminster Bridge, London, SE17EH, UK. carly.welch@kcl.ac.uk.
  • Animesh Acharjee
    College of Medicine and Health, School of Medical Sciences, Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Rebecca Birch
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • João Pedro de Magalhães
    Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
  • Niharika A Duggal
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Alison Hainsworth
    Department of Colorectal Surgery, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, 12th Floor, Westminster Bridge, London, SE17EH, UK.
  • Jose R Hombrebueno
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Simon W Jones
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Jonathan Lewis
    Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
  • Ali Mazaheri
    School of Psychology, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Helen M McGettrick
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Thomas Nicholson
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Judith Partridge
    Department of Twin Research & Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, 3rd Floor South Wing D Block, St Thomas' Campus, Westminster Bridge, London, SE17EH, UK.
  • Thomas Pinkney
    Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Claire J Steves
    Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Kristina Tomkova
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Daisy Wilson
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
  • Thomas A Jackson
    Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.