Therapeutic effect and concomitant toxicity of hydrargyrum chloratum compositum on chronic difficult-to-heal wounds in rats.

Journal: Journal of ethnopharmacology
PMID: 40216041

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Hydrargyrum chloratum compositum(Hcc) is a traditional Chinese medicine for external use, with the efficacy of 'transforming corrosion and pulling out toxins, removing corrosion and regenerating muscles'. The main components are mercuric chloride (HgCl) and mercurous chloride (HgCl), which have antibacterial, corrosive and tissue repairing effects. However, the therapeutic mechanism and toxicity risk of its topical application for treating difficult-to-heal wounds have not been clearly explained.

Authors

  • Yu Yang
    Department of Obstetrics & Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University, Xian, Shaanxi, China.
  • Ping Huang
    Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Jingjing Yang
    Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University Jinan 250061 China yanyan.jiang@sdu.edu.cn.
  • Jin Wang
    Cells Vision (Guangzhou) Medical Technology Inc., Guangzhou, China. Electronic address: wangjin@cellsvision.com.
  • Qinwan Huang
    School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China; State Key Laboratory of Southwestern Chinese Medicine Resources, China. Electronic address: Huangqinwan@cdutcm.edu.cn.

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