Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis.

Journal: Biology direct
Published Date: Jul 15, 2025

Abstract

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary disease characterized by alveolar structural destruction and fibrosis. In recent years, efferocytosis has been recognized as playing a crucial role in the occurrence and progression of IPF. This study aimed to identify and regulate key efferocytosis-related genes to elucidate their potential roles and clinical significance in IPF.

Authors

  • Qian Jin
    Department of Respiratory Medicine, Beijing Hospital of Traditional Chinese Medicine, Affiliated to Capital Medical University, Beijing, China.
  • Yi Kang
    Beijing University of Chinese Medicine, Beijing, China.
  • Wenwen Jin
    Medical Engineering Technology and Data Mining Institute, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Ying Liu
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
  • Qian Chen
    Department of Pain Medicine Guizhou Provincial Orthopedics Hospital Guiyang Guizhou China.
  • Jian Liu
    Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
  • Yali Guo
    Department of Respiratory Medicine, Beijing Hospital of Traditional Chinese Medicine, Affiliated to Capital Medical University, Beijing, China.
  • Yuguang Wang
    School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.

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