Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.

Journal: BMC genomics
Published Date: Jul 29, 2025

Abstract

BACKGROUND: Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the neuroendocrine system plays a central role in HS responses by activating the hypothalamic-pituitary-adrenal and sympathetic-adrenal-medullary axes. This study explores the neural transcriptomic changes and metabolomic profile subjected to HS, aiming to unravel the complexity of nervous adaptive responses, including the disrupted lipid metabolism, impaired immunity, and neural damage processes.

Authors

  • Bingxing An
    Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
  • Peihao Liu
    Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Zhirui Yang
    Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Fan Ying
    MiLe Xinguang Agricultural and Animal Industrials Corporation, MiLe, 652300, China.
  • Dawei Liu
    Department of Anesthesiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
  • Jie Wen
    Bio-Computing Research Center, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen, 518055, Guangdong, China; Shenzhen Medical Biometrics Perception and Analysis Engineering Laboratory, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, Guangdong, China.
  • Guiping Zhao
    Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing, 100193, China. zhaoguiping@caas.cn.

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