AIMC Topic: Adenosine
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Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.
BMC genomics
Jul 29, 2025
BACKGROUND: Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the n...
Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells.
Functional & integrative genomics
Jul 9, 2025
The role of epitranscriptomic changes in the development of acquired endocrine therapy (ET)- resistance in estrogen receptor α (ER) expressing breast cancer (BC) is unknown. We tested the hypothesis that inhibition of METTL3, the methyltransferase re...
Interpretability-guided RNA N-methyladenosine modification site prediction with invertible neural networks.
Communications biology
Jul 8, 2025
As one of the most common and abundant post-transcriptional modifications, N-methyladenosine (mA) has been extensively studied for its essential regulatory role in gene expression and cell functions. The location of mA RNA modification sites, however...
Computational models for prediction of m6A sites using deep learning.
Methods (San Diego, Calif.)
Apr 21, 2025
RNA modifications play a crucial role in enhancing the structural and functional diversity of RNA molecules and regulating various stages of the RNA life cycle. Among these modifications, N6-Methyladenosine (m6A) is the most common internal modificat...
TransRM: Weakly supervised learning of translation-enhancing N6-methyladenosine (mA) in circular RNAs.
International journal of biological macromolecules
Feb 27, 2025
As our understanding of Circular RNAs (circRNAs) continues to expand, accumulating evidence has demonstrated that circRNAs can interact with microRNAs and RNA-binding proteins to modulate gene expression. More importantly, a subset of circRNAs has be...
Integration of 101 machine learning algorithm combinations to unveil m6A/m1A/m5C/m7G-associated prognostic signature in colorectal cancer.
Scientific reports
Feb 18, 2025
Colorectal cancer (CRC) is the most common malignancy in the digestive system, with a lower 5-year overall survival rate. There is increasing evidence showing that RNA modification regulators such as m1A, m5C, m6A, and m7G play crucial roles in tumor...
Feedback regulation of mA modification creates local auxin maxima essential for rice microsporogenesis.
Developmental cell
Jan 13, 2025
N-methyladenosine (mA) RNA modification and its effectors control various plant developmental processes, yet whether and how these effectors are transcriptionally controlled to confer functional specificity so far remain elusive. Herein, we show that...
A machine learning-based immune response signature to facilitate prognosis prediction in patients with endometrial cancer.
Scientific reports
Dec 28, 2024
Endometrial cancer is the most prevalent form of gynecologic malignancy, with a significant surge in incidence among youngsters. Although the advent of the immunotherapy era has profoundly improved patient outcomes, not all patients benefit from immu...
RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders.
International journal of molecular sciences
Dec 3, 2024
Mental health disorders are devastating illnesses, often misdiagnosed due to overlapping clinical symptoms. Among these conditions, bipolar disorder, schizophrenia, and schizoaffective disorder are particularly difficult to distinguish, as they share...
Identification of diagnostic biomarkers and molecular subtype analysis associated with m6A in Tuberculosis immunopathology using machine learning.
Scientific reports
Dec 2, 2024
Tuberculosis (TB), ranking just below COVID-19 in global mortality, is a highly complex infectious disease involving intricate immunological molecules, diverse signaling pathways, and multifaceted immune processes. N6-methyladenosine (m6A), a critica...
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