BACKGROUND: Sepsis and atrial fibrillation are complex, life-threatening medical conditions affecting approximately 49 million individuals globally, characterized by exceptionally high mortality rates. Lipid metabolism abnormalities play a critical r...
Meningioma, the most prevalent primary intracranial tumor, presents significant clinical challenges due to unclear molecular mechanisms underlying its progression from low-grade (LG) to high-grade (HG) and lack of grade-specific biomarkers. Here, we ...
BACKGROUND: Lipids play a vital role in health and disease, but changes to their circulating levels and the link with schizophrenia remains poorly characterized. This study aimed to investigate the pathological lipid profiles in patients with first-e...
Mitochondrial dysfunction and the accumulation of lipid droplets (LD) contribute to the pathogenesis of liver diseases. Mitochondria bound to LD, termed peridroplet mitochondria (PDM), form a subpopulation with distinct functions compared to cytoplas...
Colon cancer is one of the leading causes of cancer-related mortality, with liver metastasis commonly complicating its progression and significantly worsening patient prognosis. This study aims to explore the relationship between liver metastasis in ...
BACKGROUND: Considering the complex and close-knit relationship between non-alcoholic fatty liver disease (NAFLD) and the metabolic status, this study aimed to identify lipid metabolism-related genes (LMGs), construct an effective diagnostic model, a...
Fatty acid metabolism is critically involved in glioblastoma (GBM) pathogenesis; however, its regulatory mechanisms remain incompletely understood. In this study, we identified biliverdin reductase A (BLVRA) as a novel metabolic driver and prognostic...
This study explores the association of lipid metabolism disruption and Oral Squamous Cell Carcinoma (OSCC). We aim to identify specific lipid biomarkers and therapeutic targets for OSCC. We included 78 OSCC patients and 80 healthy controls, and appli...
Cardiovascular disease progression is characterised by the dysregulation of lipid metabolism and pro-atherogenic effects of adipose tissue signalling. Recent findings from the analysis of transcriptomic data in bulk tissue has enabled these insights ...
Osteonecrosis of the femoral head (ONFH) is a debilitating condition frequently associated with dysregulation in lipid metabolism. The objective of this study was to identify potential biomarkers for ONFH through various analytical methods and experi...
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