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Hypothalamus

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Heatstroke death identification using ATR-FTIR spectroscopy combined with a novel multi-organ machine learning approach.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
With global warming, the number of deaths due to heatstroke has drastically increased. Nevertheless, there are still difficulties with the forensic assessment of heatstroke deaths, including the absence of particular organ pathological abnormalities ...

A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids.

Communications biology
We use three-dimensional culture systems of human pluripotent stem cells for differentiation into pituitary organoids. Three-dimensional culture is inherently characterized by its ability to induce heterogeneous cell populations, making it difficult ...

Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation.

Scientific reports
Primary lateral sclerosis (PLS) is a motor neuron disease (MND) which mainly affects upper motor neurons. Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized by cata...

Chemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques.

Analytical biochemistry
This study employed Fourier transform infrared (FTIR) spectroscopy to determine the chemical composition of brain tissues and the changes induced by irisin at doses of 50 mg and 100 mg. Brain tissues were collected from control rats and those adminis...