Natural History of Cerebral Aneurysms: Risk Factors for Rupture and Implications for Management.

Journal: Neuroimaging clinics of North America
Published Date: Aug 1, 2025

Abstract

Intracranial aneurysms, affecting 2% to 3% of adults, present a significant health challenge due to their potential for sudden rupture, which entails high morbidity, mortality, and economic costs. Advances in computational neuroimaging, computational tools, and artificial intelligence (AI) have shifted risk assessment from population-based models to individualized approaches. This review focuses on the impact cerebral aneurysm epidemiology has on risk, emphasizing the integration of clinical risk scales with advanced imaging and AI for enhanced stratification and monitoring. This review advocates for a dynamic, multimodal approach that leverages technological and scientific advances to quantify risk to optimize cerebral aneurysm management and outcomes.

Authors

  • Daniel P Gibson
    Department of Interventional Neuroradiology, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Charles G Kulwin
    Department of Neurosurgery, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Kushal J Shah
    Department of Neurosurgery, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Troy D Payner
    Department of Neurosurgery, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Andrew J DeNardo
    Department of Interventional Neuroradiology, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Krishna Amuluru
    Department of Interventional Neuroradiology, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA.
  • Daniel H Sahlein
    Department of Interventional Neuroradiology, Goodman Campbell Brain and Spine at Ascension St. Vincent Hospital, Carmel, Indiana, USA. Electronic address: dsahlein@goodmancampbell.com.

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