Improving risk stratification of PI-RADS 3 + 1 lesions of the peripheral zone: expert lexicon of terms, multi-reader performance and contribution of artificial intelligence.

Journal: Cancer imaging : the official publication of the International Cancer Imaging Society
Published Date:

Abstract

BACKGROUND: According to PI-RADS v2.1, peripheral PI-RADS 3 lesions are upgraded to PI-RADS 4 if dynamic contrast-enhanced MRI is positive (3+1 lesions), however those lesions are radiologically challenging. We aimed to define criteria by expert consensus and test applicability by other radiologists for sPC prediction of PI-RADS 3+1 lesions and determine their value in integrated regression models.

Authors

  • Philip A Glemser
    Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
  • Nils Netzer
  • Christian H Ziener
    Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
  • Markus Wilhelm
    Breast Diagnostics Munich, Sonnenstraße 29, Munich, Germany.
  • Thomas Hielscher
    Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kevin Sun Zhang
    Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
  • Magdalena Görtz
    Department of Urology, University of Heidelberg Medical Center, Heidelberg, Germany.
  • Viktoria Schütz
    Department of Urology, University of Heidelberg Medical Center, Heidelberg, Germany.
  • Albrecht Stenzinger
    From the Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (P.S., J.P.R., P.K., H.P.S., D.B.); Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany (S.K., K.H.M.H.); Department of Urology, University of Heidelberg Medical Center, Heidelberg, Germany (J.P.R., M.H.); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany (M.W.); Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany (P.K.); Junior Group Medical Imaging and Radiology-Cancer Prevention, German Cancer Research Center (DKFZ), Heidelberg, Germany (S.B.); Division of Medical Physics, German Cancer Research Center (DKFZ), Heidelberg, Germany (T.A.K.); Institute of Pathology, University of Heidelberg Medical Center, Heidelberg, Germany (A.S.); and German Cancer Consortium (DKTK), Heidelberg, Germany (H.P.S., K.H.M.H., D.B.).
  • Markus Hohenfellner
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.
  • Heinz-Peter Schlemmer
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.
  • David Bonekamp
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.