Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis.

Journal: Arthritis research & therapy
Published Date: Aug 20, 2025

Abstract

BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disorder characterized by multi-organ involvement. Early identification and accurate diagnosis of AAV is crucial for improving prognosis. However, research on biomarkers associated with AAV is limited. This study aimed to explore novel biomarkers for AAV through transcriptomic data analysis and Mendelian randomization (MR).

Authors

  • Yujia Wang
    School of EECS, Penn State, University Park, PA, 16802, U.S.A. upcheers@gmail.com.
  • Zhimin Chen
    Chengdu University of TCM, Chengdu 611137, China.
  • Kaiqi Huang
    Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
  • Keng Ye
    Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
  • Shiwei He
    School of Traffic and Transportation, Beijing Jiaotong University, Beijing 100044, China.
  • Yanfang Xu
    Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China.
  • Hong Chen
    Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

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