Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma.

Journal: Human genomics
Published Date: Aug 29, 2025

Abstract

BACKGROUND: Mitotic catastrophe (MC) is a well-recognized endogenous mechanism of tumor cell death, characterized as a delayed cell death process associated with aberrant mitosis. However, its prognostic significance in the context of intratumoral heterogeneity in esophageal squamous cell carcinoma (ESCC) remains largely unexplored.

Authors

  • Shuang Li
    Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Zheng Tao
    Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • Nan Wang
    Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Yazhou Liu
    Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • Kai Xie
    National Demonstration Center for Experimental Electrical and Electronic Education, Yangtze University, Jingzhou 434023, China. 500646@yangtzeu.edu.cn.
  • Haitao Ma
    Technical Service Site, Beijing Benz Automotive Co. Ltd., Beijing 100176, China.

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