Interpretable machine learning model for prediction functional cure in chronic hepatitis B patients receiving Peg-IFN therapy: A multi-center study.

Journal: International journal of medical informatics
Published Date: Apr 19, 2025

Abstract

BACKGROUND: Functional cure is the ideal treatment goal for chronic hepatitis B (CHB) treatment. We developed and validated machine learning (ML) models to predict functional cure in CHB patients.

Authors

  • Peiyu Zheng
    Department of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, China; Graduate School of Shanxi Medical University, Taiyuan, China.
  • Peifeng He
    School of Management, Shanxi Medical University, Taiyuan, China; Shanxi Key Laboratory of Big Data for Clinical Decision Research (Shanxi Medical University), Jinzhong, China.
  • Ying Guo
    National Institutes for Food and Drug Control, Beijing, 100050, China.
  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Qinying Wang
    Department of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: wangqy8118@163.com.

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