The Development and Evaluation of a Convolutional Neural Network for Cutaneous Melanoma Detection in Whole Slide Images.

Journal: Archives of pathology & laboratory medicine
Published Date: Sep 1, 2025

Abstract

CONTEXT.—: The current melanoma staging system does not account for 26% of the variance seen in melanoma-specific survival, therefore our ability to predict patient outcome is not fully elucidated. Morphology may be of greater significance than in other solid tumors, with Breslow thickness remaining the strongest prognostic indicator despite being subject to high levels of interobserver variation. The application of convolutional neural networks to whole slide images affords objective morphologic metrics, which may reveal new insights into patient prognosis.

Authors

  • Emily L Clarke
    From the Department of Histopathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom (Clarke, Merchant, Treanor).
  • Derek Magee
    University of Leeds, Leeds, UK.
  • Julia Newton-Bishop
    Leeds Institute for Medical Research, University of Leeds, Leeds, United Kingdom (Newton-Bishop).
  • William Merchant
    From the Department of Histopathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom (Clarke, Merchant, Treanor).
  • Robert Insall
    School of Cancer Sciences, University of Glasgow, Scotland, UK; Cancer Research UK Scotland Institute, Scotland, UK; Division of Biosciences, University College London, England, UK.
  • Nigel G Maher
    Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
  • Richard A Scolyer
    Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
  • Grace Farnworth
    the Division of Pathology and Data Analytics, University of Leeds, Leeds, United Kingdom (Clarke, Farnworth, Ali, Treanor).
  • Anisah Ali
    the Division of Pathology and Data Analytics, University of Leeds, Leeds, United Kingdom (Clarke, Farnworth, Ali, Treanor).
  • Sally O'Shea
    Dermatology Department, South Infirmary Victoria University Hospital, Cork, Ireland (O'Shea).
  • Darren Treanor
    Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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