Influence of renal function on blood pressure control and outcome in thrombolyzed patients after acute ischemic stroke: analysis of the ENCHANTED trial.

Journal: Frontiers in endocrinology
PMID:

Abstract

BACKGROUND: The effect of renal impairment in patients who receive intravenous thrombolysis for acute ischemic stroke (AIS) is unclear. We aimed to determine the associations of renal impairment and clinical outcomes and any modification of the effect of intensive versus guideline-recommended blood pressure (BP) control in the BP arm of the International Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).

Authors

  • Xinwen Ren
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Chen Chen
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Xia Wang
    Department of Neurology, The Sixth People's Hospital of Huizhou City, Huizhou, China.
  • Qiang Li
    Department of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.
  • Yang Zhao
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Shoujiang You
    Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of SooChow University, Suzhou, China.
  • Menglu Ouyang
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Thompson Robinson
    Department of Cardiovascular Sciences and National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, Leicester, United Kingdom.
  • Richard I Lindley
    Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
  • Hisatomi Arima
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Xiaoying Chen
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • John Chalmers
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Craig S Anderson
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Lili Song
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.