Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data.

Journal: The Lancet. Respiratory medicine
PMID: 26003389

Abstract

BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease that distorts pulmonary architecture, leading to hypoxia, respiratory failure, and death. Diagnosis is difficult because other interstitial lung diseases have similar radiological and histopathological characteristics. A usual interstitial pneumonia pattern is a hallmark of idiopathic pulmonary fibrosis and is essential for its diagnosis. We aimed to develop a molecular test that distinguishes usual interstitial pneumonia from other interstitial lung diseases in surgical lung biopsy samples. The eventual goal of this research is to develop a method to diagnose idiopathic pulmonary fibrosis without the patient having to undergo surgery.

Authors

  • Su Yeon Kim
  • James Diggans
    Veracyte, Inc., South San Francisco, California, USA.
  • Dan Pankratz
    Veracyte, South San Francisco, CA, USA.
  • Jing Huang
    Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Moraima Pagan
  • Nicole Sindy
    Veracyte, South San Francisco, CA, USA.
  • Ed Tom
  • Jessica Anderson
    Veracyte, South San Francisco, CA, USA.
  • Yoonha Choi
    Veracyte, South San Francisco, CA, USA.
  • David A Lynch
    National Jewish Health, Denver, CO, USA.
  • Mark P Steele
    Vanderbilt University, Nashville, TN, USA.
  • Kevin R Flaherty
    University of Michigan, Ann Arbor, MI, USA.
  • Kevin K Brown
    National Jewish Health, Denver, CO, USA.
  • Humam Farah
    Hannibal Clinic, Hannibal, MO, USA.
  • Michael J Bukstein
    Hannibal Clinic, Hannibal, MO, USA.
  • Annie Pardo
    Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico.
  • Moisés Selman
    Instituto Nacional de Enfermedades Respiratorias, DF, Mexico.
  • Paul J Wolters
    University of California, San Francisco, CA, USA.
  • Steven D Nathan
    Inova Fairfax Hospital, Falls Church, VA, USA.
  • Thomas V Colby
    Mayo Clinic, Scottsdale, AZ, USA.
  • Jeffrey L Myers
    University of Michigan, Ann Arbor, MI, USA.
  • Anna-Luise A Katzenstein
    SUNY Upstate Medical University, Syracuse, NY, USA.
  • Ganesh Raghu
    University of Washington Medical Center, Seattle, WA, USA.
  • Giulia C Kennedy

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