Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov.

Journal: Journal of the American Medical Informatics Association : JAMIA
Published Date:

Abstract

OBJECTIVE: Clinical trials investigating drugs that target specific genetic alterations in tumors are important for promoting personalized cancer therapy. The goal of this project is to create a knowledge base of cancer treatment trials with annotations about genetic alterations from ClinicalTrials.gov.

Authors

  • Jun Xu
    Department of Nephrology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guizhou, China.
  • Hee-Jin Lee
    University of Texas Health Science Center at Houston, Houston, TX.
  • Jia Zeng
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Yonghui Wu
    Department of Health Outcomes and Biomedical Informatics.
  • Yaoyun Zhang
    Alibaba Damo Academy, 969 West Wen Yi Road, Yu Hang District, Hangzhou, Zhejiang, China.
  • Liang-Chin Huang
    School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Amber Johnson
    Institute for Personalized Cancer Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vijaykumar Holla
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Ann M Bailey
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Trevor Cohen
    University of Washington, Seattle, WA.
  • Funda Meric-Bernstam
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Elmer V Bernstam
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Hua Xu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.