Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals.

Journal: Journal of the American Medical Informatics Association : JAMIA
Published Date: Aug 7, 2016

Abstract

OBJECTIVE: Phenotyping algorithms applied to electronic health record (EHR) data enable investigators to identify large cohorts for clinical and genomic research. Algorithm development is often iterative, depends on fallible investigator intuition, and is time- and labor-intensive. We developed and evaluated 4 types of phenotyping algorithms and categories of EHR information to identify hypertensive individuals and controls and provide a portable module for implementation at other sites.

Authors

  • Pedro L Teixeira
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Wei-Qi Wei
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Robert M Cronin
    Vanderbilt University Medical Center, Nashville, Tennessee.
  • Huan Mo
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Jacob P VanHouten
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Robert J Carroll
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Eric LaRose
    Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, 1000 N Oak Ave - ML8, Marshfield, WI 54449, USA.
  • Lisa A Bastarache
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • S Trent Rosenbloom
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Todd L Edwards
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Dan M Roden
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Thomas A Lasko
    Vanderbilt University School of Medicine, Nashville, TN.
  • Richard A Dart
    Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, 54449, USA.
  • Anne M Nikolai
    Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, 1000 N Oak Ave - ML8, Marshfield, WI 54449, USA.
  • Peggy L Peissig
    Marshfield Clinic Research Foundation, Marshfield, WI, USA.
  • Joshua C Denny
    Vanderbilt University, Nashville, TN.

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