Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants.

Journal: Medical physics
PMID: 27587029

Abstract

PURPOSE: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed "incision-less surgery." Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements. A novel robotic system is proposed to position a focused ultrasound transducer accurately above the head of a neonatal patient inside an MRI machine to deliver the therapy.

Authors

  • Karl D Price
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada and The Department of Mechanical Engineering, The University of Toronto, Toronto, Ontario M5S 3G8, Canada.
  • Vivian W Sin
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Charles Mougenot
    Philips Healthcare Canada, Markham, Ontario L6C 2S3, Canada.
  • Samuel Pichardo
    Electrical Engineering, Lakehead University, Thunder Bay, Ontario P7B 5E1, Canada.
  • Thomas Looi
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada and The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9, Canada.
  • Adam C Waspe
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada and Department of Medical Imaging, The University of Toronto, Toronto, Ontario M5T 1W7, Canada.
  • James M Drake
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Neurosurgery, The University of Toronto, Toronto, Ontario M5S 1A1, Canada; and The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9, Canada.

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