Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery.

Journal: Movement disorders : official journal of the Movement Disorder Society
PMID: 27709666

Abstract

BACKGROUND: Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery for Parkinson's disease. Usually, the demarcation of the STN borders is performed manually by a neurophysiologist. The exact detection of the borders is difficult, especially detecting the transition between the STN and the substantia nigra pars reticulata. Consequently, demarcation may be inaccurate, leading to suboptimal location of the DBS lead and inadequate clinical outcomes.

Authors

  • Dan Valsky
    The Edmond and Lily Safra Center for Brain Research (ELSC), The Hebrew University, Jerusalem, Israel.
  • Odeya Marmor-Levin
    Department of Medical Neurobiology (Physiology), Institute of Medical Research - Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Marc Deffains
    Department of Medical Neurobiology (Physiology), Institute of Medical Research - Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Renana Eitan
    Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Kim T Blackwell
    Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, USA.
  • Hagai Bergman
    The Edmond and Lily Safra Center for Brain Research (ELSC), The Hebrew University, Jerusalem, Israel.
  • Zvi Israel
    Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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