Intracellular action potential (AP) recording that allows long-term monitoring is challenging because permanent membrane penetration is impossible due to cell death or resealing of perforated cell membrane. Herein, an "inherited noninvasive intracell...
Journal of neuroengineering and rehabilitation
Oct 22, 2025
The restoration of standing and walking after spinal cord injury (SCI) remains a top priority for individuals with paraplegia. Despite significant advancements in neuromodulation techniques, challenges such as limited selectivity and inconsistent out...
A detailed functional characterization of electrogenic cells, such as neurons and cardiomyocytes, by means of high-density microelectrode arrays (HD-MEAs) has emerged as a powerful approach for inferring cellular phenotypes and elucidating fundamenta...
Biosensors, such as microelectrode arrays that record in vitro neuronal activity, provide powerful platforms for studying neuroactive substances. This study presents a machine learning workflow to analyze drug-induced changes in neuronal biosensor da...
Cultured neural networks in vitro have demonstrated the biocomputing capability to recognize patterns. However, the underlying mechanisms behind information processing and pattern recognition remain less understood. Here, we developed an in vitro neu...
Retina converts light stimuli into spike firings, encoding abundant visual information critical for both fundamental studies of the visual system and therapies for visual diseases. However, probing these spikes directly from the retina is hindered by...
Intracellular electrophysiology is essential in neuroscience, cardiology, and pharmacology for studying cells' electrical properties. Traditional methods like patch-clamp are precise but low-throughput and invasive. Nanoelectrode Arrays (NEAs) offer ...
Simultaneously recording network activity and ultrastructural changes of the synapse is essential for advancing understanding of the basis of neuronal functions. However, the rapid millisecond-scale fluctuations in neuronal activity and the subtle su...
Understanding the generative mechanism between local field potentials (LFP) and neuronal spiking activity is a crucial step for understanding information processing in the brain. Up to now, most approaches have relied on simply quantifying the coupli...
International journal of computer assisted radiology and surgery
Jul 1, 2024
PURPOSE: Micro-electrode recordings (MERs) are a key intra-operative modality used during deep brain stimulation (DBS) electrode implantation, which allow for a trained neurophysiologist to infer the anatomy in which the electrode is placed. As DBS t...
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