Morinda officinalis polysaccharides inhibit the expression and activity of NOD-like receptor thermal protein domain associated protein 3 in inflammatory periodontal ligament cells by upregulating silent information regulator sirtuin 1.

Journal: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
PMID: 38597031

Abstract

OBJECTIVES: This study aims to investigate the effect of morinda officinalis polysaccharides (MOP) in inflammatory microenvironment on the expression of silent information regulator sirtuin 1 (SIRT1) and NOD-like receptor thermal protein domain associated protein 3 (NLRP3) in periodontal ligament cells.

Authors

  • Hongxuan Cai
    School of Stomatology, Hainan Medical University, Haikou 570100, China.
  • Zheng'an Wang
    Dept. of Stomatology, The First Affiliated Hospital of Hainan Medical College, Haikou 570100, China.
  • Zan Zhang
    School of Stomatology, Hainan Medical University, Haikou 570100, China.
  • Jingyi Dai
    School of Stomatology, Hainan Medical University, Haikou 570100, China.
  • Weixing Si
    School of Stomatology, Hainan Medical University, Haikou 570100, China.
  • Qiya Fu
    School of Stomatology, Hainan Medical University, Haikou 570100, China.
  • Jingwen Yang
    Dept. of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100080, China.
  • Yaguang Tian
    Dept. of Stomatology, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570100, China.

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