AIMC Topic: NLR Family, Pyrin Domain-Containing 3 Protein

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Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Animals Male Deep Learning Mice Blood-Brain Barrier NLR Family, Pyrin Domain-Containing 3 Protein Infarction, Middle Cerebral Artery RNA, Small Interfering Infrared Rays Nanoparticles Disease Models, Animal Mice, Inbred C57BL Ischemic Stroke
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Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis.

Cells Dec 30, 2024
The NLRP3 inflammasome, plays a critical role in the pathogenesis of rheumatoid arthritis (RA) by activating inflammatory cytokines such as IL1β and IL18. Targeting NLRP3 has emerged as a promising therapeutic strategy for RA. In this study, a multid...
Databases, Chemical Machine Learning Quantitative Structure-Activity Relationship NLR Family, Pyrin Domain-Containing 3 Protein Arthritis, Rheumatoid Molecular Dynamics Simulation Chemical Phenomena Antirheumatic Agents
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Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases.

Journal of medicinal chemistry Sep 20, 2024
The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report the development of SN3-1, a novel orally potent NLRP3 inhibitor, designed ...
Humans Animals Male Inflammasomes Crystallography, X-Ray Inflammation Drug Discovery Mice, Inbred C57BL Deep Learning Structure-Activity Relationship Mice NLR Family, Pyrin Domain-Containing 3 Protein
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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
DNA-Binding Proteins Inflammation Rats, Sprague-Dawley Lipopolysaccharides Plant Leaves Animals Mice Rats NLR Family, Pyrin Domain-Containing 3 Protein Neuroinflammatory Diseases Anti-Infective Agents Pyroptosis Microglia Tumor Necrosis Factor-alpha Stroke NF-kappa B Interleukin-6 Infarction, Middle Cerebral Artery Anti-Inflammatory Agents
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Multinomial classification of NLRP3 inhibitory compounds based on large scale machine learning approaches.

Molecular diversity Jul 7, 2023
The role of NLRP3 inflammasome in innate immunity is newly recognized. The NLRP3 protein is a family of nucleotide-binding and oligomerization domain-like receptors as well as a pyrin domain-containing protein. It has been shown that NLRP3 may contri...
Humans Machine Learning ROC Curve NLR Family, Pyrin Domain-Containing 3 Protein Quantitative Structure-Activity Relationship
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Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice.

Journal of food and drug analysis Apr 19, 2017
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demon...
Mice Plant Extracts Inflammation Signal Transduction Biomarkers Endotoxins Plant Leaves Animals NF-kappa B Inflammation Mediators Male Anti-Inflammatory Agents Acrolein Oils, Volatile Humans NLR Family, Pyrin Domain-Containing 3 Protein Cinnamomum Cytokines
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Repurposing FDA-approved drugs as NLRP3 inhibitors against inflammatory diseases: machine learning and molecular simulation approaches.

Journal of biomolecular structure & dynamics May 1, 2025
Activation of NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) has been associated with multiple chronic pathologies, including diabetes, atherosclerosis, and rheumatoid arthritis. Moreover, histone deacetylases (HDACs), specifical...
Protein Binding Inflammation United States Drug Repositioning Humans Machine Learning Molecular Docking Simulation Drug Approval NLR Family, Pyrin Domain-Containing 3 Protein Molecular Dynamics Simulation Inflammasomes United States Food and Drug Administration
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Morinda officinalis polysaccharides inhibit the expression and activity of NOD-like receptor thermal protein domain associated protein 3 in inflammatory periodontal ligament cells by upregulating silent information regulator sirtuin 1.

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Dec 1, 2023
OBJECTIVES: This study aims to investigate the effect of morinda officinalis polysaccharides (MOP) in inflammatory microenvironment on the expression of silent information regulator sirtuin 1 (SIRT1) and NOD-like receptor thermal protein domain assoc...
Morinda Protein Domains Lipopolysaccharides Animals NLR Proteins NLR Family, Pyrin Domain-Containing 3 Protein Rats Periodontal Ligament Sirtuin 1 Inflammation Interleukin-18
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[The Protective Effect of Tanshinone IIA on Oxygen-glucose Deprivation and Reperfusion Injury of MicrogliaThrough the NLRP3 Inflammatory Signaling Pathway].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Sep 1, 2016
OBJECTIVES: To investigate the protective effect of Tanshinone IIA (TSA) on oxygen-glucose deprivation and reperfusion (OGD/R) injury of BV-2 cell and its NLRP3 inflammatory signaling pathway.
Signal Transduction Cell Line Cytokines Oxygen Microglia Animals NLR Family, Pyrin Domain-Containing 3 Protein Reperfusion Injury Mice Glucose Abietanes
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[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Sep 1, 2016
OBJECTIVES: Study the gene and protein expression of NACHT-PYD-containing protein 3 (NALP3) inflammasome and extracellular regulated protein kinase (ERK), the intervention effects of sodium ferulate (SF) in human lung epithelial cells A549 under oxid...
Inflammasomes MAP Kinase Signaling System Coumaric Acids Flavonoids A549 Cells Interleukin-1beta NLR Family, Pyrin Domain-Containing 3 Protein Humans Hydrogen Peroxide Oxidative Stress
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