AIMC Topic: Interleukin-18

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Machine learning implicates the IL-18 signaling axis in severe asthma.

JCI insight Nov 8, 2021
Asthma is a common disease with profoundly variable natural history and patient morbidity. Heterogeneity has long been appreciated, and much work has focused on identifying subgroups of patients with similar pathobiological underpinnings. Previous st...
Machine Learning Female Humans Male Case-Control Studies Interleukin-18 Adult Asthma
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Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy.

Diabetes & metabolic syndrome Nov 10, 2018
AIMS: Diabetic nephropathy (DN) is a serious microvascular complication of a longstanding hyperglycemia. This study aims to evaluate whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and urinary Interleukin-18 possess a better diagnos...
Creatinine Serum Albumin, Human Humans Lipocalin-2 Adult Diabetes Mellitus, Type 2 Interleukin-18 Male Biomarkers Diabetic Nephropathies Middle Aged Female
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Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.

Journal of neurovirology Dec 19, 2017
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Rats, Inbred F344 Maze Learning Rats, Transgenic Endotoxins Binge Drinking Locomotion Corpus Striatum Gene Expression Interleukin-6 NF-kappa B Rats Animals Male HIV-1 Disease Models, Animal Interleukin-18 HIV Infections Docosahexaenoic Acids
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Morinda officinalis polysaccharides inhibit the expression and activity of NOD-like receptor thermal protein domain associated protein 3 in inflammatory periodontal ligament cells by upregulating silent information regulator sirtuin 1.

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Dec 1, 2023
OBJECTIVES: This study aims to investigate the effect of morinda officinalis polysaccharides (MOP) in inflammatory microenvironment on the expression of silent information regulator sirtuin 1 (SIRT1) and NOD-like receptor thermal protein domain assoc...
Protein Domains NLR Proteins Periodontal Ligament NLR Family, Pyrin Domain-Containing 3 Protein Interleukin-18 Inflammation Animals Morinda Sirtuin 1 Lipopolysaccharides Rats
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[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].

Zhonghua wei zhong bing ji jiu yi xue Oct 1, 2015
OBJECTIVE: To investigate the role and its mechanism of the NOD-like receptor 3 (NLRP3) inflammasome in alveolar macrophages in ventilator-induced lung injury (VILI) in rats.
Lung RNA, Messenger Male Respiration, Artificial Carrier Proteins Tidal Volume Interleukin-1beta Rats Rats, Sprague-Dawley Ventilator-Induced Lung Injury Animals Random Allocation Interleukin-18 Caspase 1 Bronchoalveolar Lavage Fluid Inflammasomes Macrophages, Alveolar NF-kappa B NLR Family, Pyrin Domain-Containing 3 Protein
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