Identify and analysis crotonylation sites in histone by using support vector machines.

Journal: Artificial intelligence in medicine
Published Date: Nov 1, 2017

Abstract

OBJECTIVE: Lysine crotonylation (Kcr) is a newly discovered histone posttranslational modification, which is specifically enriched at active gene promoters and potential enhancers in mammalian cell genomes. Although lysine crotonylation sites can be correctly identified with high-resolution mass spectrometry, the experimental methods are time-consuming and expensive. Therefore, it is necessary to develop computational methods to deal with this problem.

Authors

  • Wang-Ren Qiu
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen, 333403, China; Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: qiuone@163.com.
  • Bi-Qian Sun
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen, 333403, China. Electronic address: Sunbiq@126.com.
  • Hua Tang
    Chongqing Institute for Food and Drug Control, Chongqing 401121, China.
  • Jian Huang
    Center for Informational Biology, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu 611731, P. R. China.
  • Hao Lin
    Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou, Zhejiang, China.

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