Digital-to-biological converter for on-demand production of biologics.

Journal: Nature biotechnology
PMID: 28553942

Abstract

Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.

Authors

  • Kent S Boles
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • Krishna Kannan
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • John Gill
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Martina Felderman
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • Heather Gouvis
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • Bolyn Hubby
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • Kurt I Kamrud
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • J Craig Venter
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • Daniel G Gibson
    Synthetic Genomics, Inc., La Jolla, California, USA.

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