An Intelligent Parkinson's Disease Diagnostic System Based on a Chaotic Bacterial Foraging Optimization Enhanced Fuzzy KNN Approach.

Journal: Computational and mathematical methods in medicine
Published Date:

Abstract

Parkinson's disease (PD) is a common neurodegenerative disease, which has attracted more and more attention. Many artificial intelligence methods have been used for the diagnosis of PD. In this study, an enhanced fuzzy -nearest neighbor (FKNN) method for the early detection of PD based upon vocal measurements was developed. The proposed method, an evolutionary instance-based learning approach termed CBFO-FKNN, was developed by coupling the chaotic bacterial foraging optimization with Gauss mutation (CBFO) approach with FKNN. The integration of the CBFO technique efficiently resolved the parameter tuning issues of the FKNN. The effectiveness of the proposed CBFO-FKNN was rigorously compared to those of the PD datasets in terms of classification accuracy, sensitivity, specificity, and AUC (area under the receiver operating characteristic curve). The simulation results indicated the proposed approach outperformed the other five FKNN models based on BFO, particle swarm optimization, Genetic algorithms, fruit fly optimization, and firefly algorithm, as well as three advanced machine learning methods including support vector machine (SVM), SVM with local learning-based feature selection, and kernel extreme learning machine in a 10-fold cross-validation scheme. The method presented in this paper has a very good prospect, which will bring great convenience to the clinicians to make a better decision in the clinical diagnosis.

Authors

  • Zhennao Cai
    College of Physics and Electronic Information Engineering, Wenzhou University, Wenzhou, China.
  • Jianhua Gu
    Office of National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Caiyun Wen
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Dong Zhao
    Collaborative Innovation Center of Judicial Civilization, Key Laboratory of Evidence Science, Ministry of Education, China University of Political Science and Law, Beijing 100088, China.
  • Chunyu Huang
    Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, China.
  • Hui Huang
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Changfei Tong
    College of Physics and Electronic Information Engineering, Wenzhou University, Wenzhou 325035, China.
  • Jun Li
    Department of Emergency, Zhuhai Integrated Traditional Chinese and Western Medicine Hospital, Zhuhai, 519020, Guangdong Province, China. quanshabai43@163.com.
  • Huiling Chen
    College of Computer Science and Artificial Intelligence, Wenzhou University, Wenzhou 325035, China.