Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence.

Journal: Frontiers in immunology
PMID: 38390397

Abstract

INTRODUCTION: Diabetic nephropathy (DN), distinguished by detrimental changes in the renal glomeruli, is regarded as the leading cause of death from end-stage renal disease among diabetics. Cellular senescence plays a paramount role, profoundly affecting the onset and progression of chronic kidney disease (CKD) and acute kidney injuries. This study was designed to delve deeply into the pathological mechanisms between glomerulus-associated DN and cellular senescence.

Authors

  • Donglin Sun
    Department of Urology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
  • Shuqi Wei
    Center for Cancer and Immunology Research, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Dandan Wang
    Department of Traditional Chinese Medicine Orthopedics and Traumatology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Min Zeng
    Nephrology Department, Affiliated Hospital of Southern Medical University: Shenzhen Longhua New District People's Hospital, Shenzhen, China.
  • Yihao Mo
    Nephrology Department, Affiliated Hospital of Southern Medical University: Shenzhen Longhua New District People's Hospital, Shenzhen, China.
  • Huafeng Li
    Nephrology Department, Affiliated Hospital of Southern Medical University: Shenzhen Longhua New District People's Hospital, Shenzhen, China.
  • Caixing Liang
    Nephrology Department, Affiliated Hospital of Southern Medical University: Shenzhen Longhua New District People's Hospital, Shenzhen, China.
  • Lu Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
  • Jun Wei Zhang
    Nephrology Department, Affiliated Hospital of Southern Medical University: Shenzhen Longhua New District People's Hospital, Shenzhen, China.
  • Li Wang
    College of Marine Electrical Engineering, Dalian Maritime University, Dalian, China.

Keywords

External Resources

Popular Topics
Recent Journals