Using machine learning on cardiorespiratory fitness data for predicting hypertension: The Henry Ford ExercIse Testing (FIT) Project.

Journal: PloS one
Published Date:

Abstract

This study evaluates and compares the performance of different machine learning techniques on predicting the individuals at risk of developing hypertension, and who are likely to benefit most from interventions, using the cardiorespiratory fitness data. The dataset of this study contains information of 23,095 patients who underwent clinician- referred exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009 and had a complete 10-year follow-up. The variables of the dataset include information on vital signs, diagnosis and clinical laboratory measurements. Six machine learning techniques were investigated: LogitBoost (LB), Bayesian Network classifier (BN), Locally Weighted Naive Bayes (LWB), Artificial Neural Network (ANN), Support Vector Machine (SVM) and Random Tree Forest (RTF). Using different validation methods, the RTF model has shown the best performance (AUC = 0.93) and outperformed all other machine learning techniques examined in this study. The results have also shown that it is critical to carefully explore and evaluate the performance of the machine learning models using various model evaluation methods as the prediction accuracy can significantly differ.

Authors

  • Sherif Sakr
    King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King AbdulAziz Cardiac Center, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia.
  • Radwa Elshawi
    Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Amjad Ahmed
    King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • Waqas T Qureshi
    Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.
  • Clinton Brawner
    Heart and Vascular Institute, Henry Ford Hospital System, Detroit, MI, United States of America.
  • Steven Keteyian
    Heart and Vascular Institute, Henry Ford Hospital System, Detroit, MI, United States of America.
  • Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland.
  • Mouaz H Al-Mallah
    Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michigan; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King AbdulAziz Cardiac Center, Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia. Electronic address: mouaz74@gmail.com.