Computer-assisted liver graft steatosis assessment via learning-based texture analysis.

Journal: International journal of computer assisted radiology and surgery
Published Date:

Abstract

PURPOSE: Fast and accurate graft hepatic steatosis (HS) assessment is of primary importance for lowering liver dysfunction risks after transplantation. Histopathological analysis of biopsied liver is the gold standard for assessing HS, despite being invasive and time consuming. Due to the short time availability between liver procurement and transplantation, surgeons perform HS assessment through clinical evaluation (medical history, blood tests) and liver texture visual analysis. Despite visual analysis being recognized as challenging in the clinical literature, few efforts have been invested to develop computer-assisted solutions for HS assessment. The objective of this paper is to investigate the automatic analysis of liver texture with machine learning algorithms to automate the HS assessment process and offer support for the surgeon decision process.

Authors

  • Sara Moccia
    Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy; Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genoa, Italy. Electronic address: sara.moccia@iit.it.
  • Leonardo S Mattos
  • Ilaria Patrini
    Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, MI, Italy.
  • Michela Ruperti
    Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, MI, Italy.
  • Nicolas Poté
    Department of Pathology, Hôpital Beaujon, DHU UNITY, AP-HP, Clichy, France.
  • Federica Dondero
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
  • François Cauchy
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
  • Ailton Sepulveda
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
  • Olivier Soubrane
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
  • Elena De Momi
  • Alberto Diaspro
    Optical Nanoscopy and NIC@IIT, CHT, Istituto Italiano di Tecnologia, Via Enrico Melen 83B, 16152 Genoa, Italy.
  • Manuela Cesaretti
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.