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Liver Transplantation

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The Liver Intensive Care Unit.

Clinics in liver disease
Major advances in managing critically ill patients with liver disease have improved their prognosis and access to intensive care facilities. Acute-on-chronic liver failure (ACLF) is now a well-defined disease and these patients can be fast-tracked fo...

Machine learning for post-liver transplant survival: Bridging the gap for long-term outcomes through temporal variation features.

Computer methods and programs in biomedicine
BACKGROUND: The long-term survival of liver transplant (LT) recipients is essential for optimizing organ allocation and estimating mortality outcomes. While models like the Model-for-End-Stage-Liver-Disease (MELD) predict 90-day mortality on the wait...

Quantitative fibrosis identifies biliary tract involvement and is associated with outcomes in pediatric autoimmune liver disease.

Hepatology communications
BACKGROUND: Children with autoimmune liver disease (AILD) may develop fibrosis-related complications necessitating a liver transplant. We hypothesize that tissue-based analysis of liver fibrosis by second harmonic generation (SHG) microscopy with art...

Bibliometric and LDA analysis of acute rejection in liver transplantation: Emerging trends, immunotherapy challenges, and the role of artificial intelligence.

Cell transplantation
With the rising demand for liver transplantation (LT), research on acute rejection (AR) has become increasingly diverse, yet no consensus has been reached. This study presents a bibliometric and latent Dirichlet allocation (LDA) topic modeling analys...

Transforming liver transplant allocation with artificial intelligence and machine learning: a systematic review.

BMC medical informatics and decision making
BACKGROUND: The principles of urgency, utility, and benefit are fundamental concepts guiding the ethical and practical decision-making process for organ allocation; however, LT allocation still follows an urgency model.

Advanced prognostic modeling with deep learning: assessing long-term outcomes in liver transplant recipients from deceased and living donors.

Journal of translational medicine
BACKGROUND: Predicting long-term outcomes in liver transplantation remain a challenging endeavor. This research aims to harness the power of deep learning to develop an advanced prognostic model for assessing long-term outcomes, with a specific focus...

Comparison of time-to-event machine learning models in predicting biliary complication and mortality rate in liver transplant patients.

Scientific reports
Post-Liver transplantation (LT) survival rates stagnate, with biliary complications (BC) as a major cause of death. We analyzed longitudinal data with a median 19-month follow-up. BC was diagnosed with ultrasounds and MRCP. Missing data was imputed u...

Deep learning for hepatocellular carcinoma recurrence before and after liver transplantation: a multicenter cohort study.

Scientific reports
Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is a major contributor to mortality. We developed a recurrence prediction system for HCC patients before and after LT. Data from patients with HCC who underwent LT were retros...

Utilizing Machine Learning to Predict Liver Allograft Fibrosis by Leveraging Clinical and Imaging Data.

Clinical transplantation
BACKGROUND AND AIM: Liver transplant (LT) recipients may succumb to graft-related pathologies, contributing to graft fibrosis (GF). Current methods to diagnose GF are limited, ranging from procedural-related complications to low accuracy. With recent...