Disrupted functional connectivity within the default mode network and salience network in unmedicated bipolar II disorder.

Journal: Progress in neuro-psychopharmacology & biological psychiatry
PMID: 29958116

Abstract

BACKGROUND: Recent studies demonstrate that functional disruption in resting-state networks contributes to cognitive and affective symptoms of bipolar disorder (BD), however, the functional connectivity (FC) pattern underlying BD II depression within the default mode network (DMN), salience network (SN), and frontoparietal network (FPN) is still not well understood. The primary aim of this study was to explore whether the pathophysiology of BD II derived from the pattern of FC within the DMN, SN, and FPN by using seed-based FC approach of resting-state functional magnetic resonance imaging (rs-fMRI).

Authors

  • JiaYing Gong
    Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
  • Guanmao Chen
    Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Yanbin Jia
    Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Shuming Zhong
    Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Lianping Zhao
    Department of Radiology, Gansu Provincial Hospital, Gansu 730000, China.
  • Xiaomei Luo
    Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Shaojuan Qiu
    Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Shunkai Lai
    Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Zhangzhang Qi
    Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Li Huang
    National Research Center for Resettlement (NRCR), Hohai University, 1 Xikang Road, Nanjing 210098, China. lily8214@hhu.edu.cn.
  • Ying Wang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.

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