Convolutional neural networks for classification of alignments of non-coding RNA sequences.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: The convolutional neural network (CNN) has been applied to the classification problem of DNA sequences, with the additional purpose of motif discovery. The training of CNNs with distributed representations of four nucleotides has successfully derived position weight matrices on the learned kernels that corresponded to sequence motifs such as protein-binding sites.

Authors

  • Genta Aoki
    Department of Biosciences and Informatics, Keio University, Yokohama, Japan.
  • Yasubumi Sakakibara
    Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan yasu@bio.keio.ac.jp.