Unsupervised and real-time spike sorting chip for neural signal processing in hippocampal prosthesis.

Journal: Journal of neuroscience methods
Published Date: Oct 16, 2018

Abstract

BACKGROUND: Damage to the hippocampus will result in the loss of ability to form new long-term memories and cognitive disorders. At present, there is no effective medical treatment for this issue. Hippocampal cognitive prosthesis is proposed to replace damaged regions of the hippocampus to mimic the function of original biological tissue. This prosthesis requires a spike sorter to detect and classify spikes in the recorded neural signal.

Authors

  • Hao Xu
    Department of Nuclear Medicine, the First Affiliated Hospital, Jinan University, Guangzhou 510632, P.R.China.gdhyx2012@126.com.
  • Yan Han
    Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, Hangzhou 310027, China; Institute of Microelectronics and Nanoelectronics, Zhejiang University, Hangzhou 310027, China. Electronic address: hany@zju.edu.cn.
  • Xiaoxia Han
    Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, Hangzhou 310027, China; Institute of Microelectronics and Nanoelectronics, Zhejiang University, Hangzhou 310027, China.
  • Junyu Xu
    Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
  • Shen Lin
    Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
  • Ray C C Cheung
    Department of Electronic Engineering, City University of Hong Kong, 999077, Hong Kong, China.

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