Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy.

Journal: The ocular surface
PMID: 30317006

Abstract

PURPOSE: This study examined whether hyperspectral stimulated Raman scattering (hsSRS) microscopy can detect differences in meibum lipid to protein composition of normal and evaporative dry eye subjects with meibomian gland dysfunction.

Authors

  • Jerry R Paugh
    Southern California College of Optometry at Marshall B. Ketchum University, Fullerton, CA, USA. Electronic address: jpaugh@ketchum.edu.
  • Alba Alfonso-Garcia
    Department of Chemistry, University of California, Irvine, Irvine, CA, USA; University of California at Davis, Department of Biomedical Engineering, Davis, CA, USA.
  • Andrew Loc Nguyen
    Department of Mathematics, California State University Fullerton, California, USA.
  • Jeffrey L Suhalim
    Department of Biomedical Engineering, University of California, Irvine, CA, USA.
  • Marjan Farid
    Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.
  • Sumit Garg
    Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.
  • Jeremiah Tao
    Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.
  • Donald J Brown
    Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.
  • Eric O Potma
    Department of Chemistry, University of California, Irvine, Irvine, CA, USA.
  • James V Jester
    Department of Biomedical Engineering, University of California, Irvine, CA, USA; Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.

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