Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning.

Journal: Frontiers in immunology
Published Date: Jan 10, 2024

Abstract

BACKGROUND: Ischemic stroke (IS), caused by blood and oxygen deprivation due to cerebral thrombosis, has links to activated and aggregated platelets. Discovering platelet-related biomarkers, developing diagnostic models, and screening antiplatelet drugs are crucial for IS diagnosis and treatment.

Authors

  • Yifei Geng
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
  • Yuchen Liu
    Department of Internal Medicine, Peking Union Medical College Hospital, Beijing, China.
  • Min Wang
    National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou 325035, China.
  • Xi Dong
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
  • Xiao Sun
    School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China.
  • Yun Luo
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
  • Xiaobo Sun
    Department of Knee Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

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