A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy.

Journal: PloS one
PMID:

Abstract

PURPOSE: Development of a supervised machine-learning model capable of predicting clinically relevant molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) from diffusion-weighted-imaging-derived radiomic features.

Authors

  • Georgios Kaissis
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Sebastian Ziegelmayer
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Fabian Lohöfer
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Katja Steiger
    Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Hana Algül
    Department of Internal Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.
  • Alexander Muckenhuber
    Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Hsi-Yu Yen
    Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Ernst Rummeny
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Helmut Friess
    Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany.
  • Roland Schmid
    Department of Internal Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.
  • Wilko Weichert
    Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Jens T Siveke
    Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Rickmer Braren
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.