Microelectrode Recordings Validate the Clinical Visualization of Subthalamic-Nucleus Based on 7T Magnetic Resonance Imaging and Machine Learning for Deep Brain Stimulation Surgery.

Journal: Neurosurgery
PMID: 29800386

Abstract

BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a proven and effective therapy for the management of the motor symptoms of Parkinson's disease (PD). While accurate positioning of the stimulating electrode is critical for success of this therapy, precise identification of the STN based on imaging can be challenging. We developed a method to accurately visualize the STN on a standard clinical magnetic resonance imaging (MRI). The method incorporates a database of 7-Tesla (T) MRIs of PD patients together with machine-learning methods (hereafter 7 T-ML).

Authors

  • Reuben R Shamir
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
  • Yuval Duchin
    Surgical Information Sciences, Inc., Minneapolis, Minnesota.
  • Jinyoung Kim
    R&D Center, VUNO, Seoul, Republic of Korea.
  • Remi Patriat
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.
  • Odeya Marmor
    Department of Neurobiology, Institute of Medical Research-Israel Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Hagai Bergman
    The Edmond and Lily Safra Center for Brain Research (ELSC), The Hebrew University, Jerusalem, Israel.
  • Jerrold L Vitek
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota.
  • Guillermo Sapiro
    Electrical and Computer Engineering, Computer Sciences, Biomedical Engineering, and Math, Duke University, Durham, NC, 27707, United States.
  • Atira Bick
    Department of Radiology, Hadassah Medical Center, Jerusalem, Israel.
  • Ruth Eliahou
    Department of Radiology, Hadassah Medical Center, Jerusalem, Israel.
  • Renana Eitan
    Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Zvi Israel
    Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Noam Harel
    Surgical Information Sciences, Inc., Minneapolis, Minnesota.

Keywords

External Resources

Popular Topics
Recent Journals