MLSeq: Machine learning interface for RNA-sequencing data.

Journal: Computer methods and programs in biomedicine
Published Date:

Abstract

BACKGROUND AND OBJECTIVE: In the last decade, RNA-sequencing technology has become method-of-choice and prefered to microarray technology for gene expression based classification and differential expression analysis since it produces less noisy data. Although there are many algorithms proposed for microarray data, the number of available algorithms and programs are limited for classification of RNA-sequencing data. For this reason, we developed MLSeq, to bring not only frequently used classification algorithms but also novel approaches together and make them available to be used for classification of RNA sequencing data. This package is developed using R language environment and distributed through BIOCONDUCTOR network.

Authors

  • Dincer Goksuluk
    Department of Biostatistics, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.
  • Gokmen Zararsiz
    Department of Biostatistics, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.
  • Selcuk Korkmaz
    Department of Biostatistics, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.
  • Vahap Eldem
    Department of Biology, Faculty of Science, Istanbul University, 34452, Istanbul, Turkey.
  • Gozde Erturk Zararsiz
    Department of Biostatistics, School of Medicine, Erciyes University, 38030, Kayseri, Turkey.
  • Erdener Ozcetin
    Department of Industrial Engineering, Faculty of Engineering, Hitit University, 19030, Corum, Turkey.
  • Ahmet Ozturk
    Department of Biostatistics and Medical Informatics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
  • Ahmet Ergun Karaagaoglu
    Department of Biostatistics, School of Medicine, Hacettepe University, 06100, Ankara, Turkey.