Application of a Neural Network Whole Transcriptome-Based Pan-Cancer Method for Diagnosis of Primary and Metastatic Cancers.

Journal: JAMA network open
PMID:

Abstract

IMPORTANCE: A molecular diagnostic method that incorporates information about the transcriptional status of all genes across multiple tissue types can strengthen confidence in cancer diagnosis.

Authors

  • Jasleen K Grewal
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Basile Tessier-Cloutier
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Martin Jones
    East Sussex Healthcare NHS Trust, Eastbourne, UK.
  • Sitanshu Gakkhar
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Yussanne Ma
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Richard Moore
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Andrew J Mungall
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Yongjun Zhao
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Karen Gelmon
    Division of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
  • Howard Lim
    Division of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
  • Daniel Renouf
    Division of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
  • Janessa Laskin
    Division of Medical Oncology, BC Cancer, Vancouver, British Columbia, Canada.
  • Marco Marra
    Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
  • Stephen Yip
  • Steven J M Jones
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.