Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.

Journal: AJNR. American journal of neuroradiology
PMID: 31727746

Abstract

BACKGROUND AND PURPOSE: Limbic encephalitis is an autoimmune disease. A variety of autoantibodies have been associated with different subtypes of limbic encephalitis, whereas its MR imaging signature is uniformly characterized by mesiotemporal abnormalities across subtypes. Here, we hypothesized that patients with limbic encephalitis would show subtype-specific mesiotemporal structural correlates, which could be classified by supervised machine learning on an individual level.

Authors

  • L Ernst
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.).
  • B David
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.).
  • J Gaubatz
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.).
  • I Domínguez-Narciso
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.).
  • G Lüchters
    Center for Development Research (G.L.), University of Bonn, Bonn, Germany.
  • A J Becker
    Department of Neuropathology (A.J.B.).
  • B Weber
    Institute for Experimental Epileptology and Cognition Research (B.W.).
  • E Hattingen
    Department of Radiology (E.H.), University of Bonn Medical Center, Bonn, Germany.
  • C E Elger
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.).
  • T Rüber
    From the Department of Epileptology (L.E., B.D., J.G., I.D.-N., C.E.E., T.R.) theodor.rueber@ukbonn.de.

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