AIMC Topic: Intracellular Signaling Peptides and Proteins

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Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.

Science translational medicine May 28, 2025
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with increased morta...
Humans Hemorrhage Apoptosis Wounds and Injuries Mice, Inbred C57BL Gasdermins Shock, Hemorrhagic Mice, Knockout Female Intracellular Signaling Peptides and Proteins Sex Characteristics Phosphate-Binding Proteins Animals Sex Factors Male Mice
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ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.

Placenta Apr 18, 2025
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Placenta Humans Autophagy Adult Pregnancy Pre-Eclampsia Animals Female Trophoblasts Mice Intracellular Signaling Peptides and Proteins Apoptosis Protein Serine-Threonine Kinases
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A morphology and secretome map of pyroptosis.

Molecular biology of the cell Apr 9, 2025
Pyroptosis represents one type of programmed cell death. It is a form of inflammatory cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated membrane pore formation. Caspase-1 initiates the inflammatory response (through ...
Phosphate-Binding Proteins Gasdermins Pyroptosis Caspase 1 Intracellular Signaling Peptides and Proteins Secretome Humans Leukocytes, Mononuclear Apoptosis Interleukin-1beta
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Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

PLoS computational biology Mar 17, 2025
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the ...
Machine Learning Animals Mice Computational Biology Neutrophils Humans Mice, Knockout Intracellular Signaling Peptides and Proteins Hematopoietic Stem Cells Neutropenia Apoptosis Mice, Inbred C57BL Protein Serine-Threonine Kinases Phosphorylation Cell Differentiation
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Discovery of novel ULK1 inhibitors through machine learning-guided virtual screening and biological evaluation.

Future medicinal chemistry Aug 15, 2024
Build a virtual screening model for ULK1 inhibitors based on artificial intelligence. Build machine learning and deep learning classification models and combine molecular docking and biological evaluation to screen ULK1 inhibitors from 13 million co...
Protein Kinase Inhibitors Intracellular Signaling Peptides and Proteins Autophagy-Related Protein-1 Homolog Humans Machine Learning Molecular Docking Simulation Drug Discovery Molecular Structure Molecular Dynamics Simulation Drug Evaluation, Preclinical
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Understanding and predicting ciprofloxacin minimum inhibitory concentration in Escherichia coli with machine learning.

Scientific reports Sep 14, 2020
It is important that antibiotics prescriptions are based on antimicrobial susceptibility data to ensure effective treatment outcomes. The increasing availability of next-generation sequencing, bacterial whole genome sequencing (WGS) can facilitate a ...
DNA Gyrase Intracellular Signaling Peptides and Proteins Ciprofloxacin Inhibitory Concentration 50 Genes, Bacterial Escherichia coli Proteins Toxicity Tests Anti-Bacterial Agents Drug Resistance, Bacterial Escherichia coli Mutation Machine Learning
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

EMBO molecular medicine Jun 24, 2020
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-c...
Artificial Intelligence Pandemics COVID-19 Cytokines Female COVID-19 Drug Treatment Drug Repositioning Humans SARS-CoV-2 Pyrazoles Middle Aged Leukocytes Intracellular Signaling Peptides and Proteins Aged Antiviral Agents Sulfonamides Protein Kinase Inhibitors Betacoronavirus Adult Liver Drug Evaluation, Preclinical Purines Pneumonia, Viral Male Coronavirus Infections Azetidines Spheroids, Cellular Protein Serine-Threonine Kinases
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Machine learning with autophagy-related proteins for discriminating renal cell carcinoma subtypes.

Scientific reports Jan 20, 2020
Machine learning techniques have been previously applied for classification of tumors based largely on morphological features of tumor cells recognized in H&E images. Here, we tested the possibility of using numeric data acquired from software-based ...
Carcinoma, Renal Cell Intracellular Signaling Peptides and Proteins Gene Expression Autophagy-Related Proteins Autophagy Humans Autophagy-Related Protein 5 Kidney Neoplasms Machine Learning Autophagy-Related Protein-1 Homolog Microtubule-Associated Proteins RNA, Messenger
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FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms.

Cancer medicine Jan 1, 2020
Early identification of metastatic or recurrent colorectal cancer (CRC) patients who will be sensitive to FOLFOX (5-FU, leucovorin and oxaliplatin) therapy is very important. We performed microarray meta-analysis to identify differentially expressed ...
Oligonucleotide Array Sequence Analysis Intracellular Signaling Peptides and Proteins Gene Expression Profiling Response Evaluation Criteria in Solid Tumors Gene Expression Regulation, Neoplastic Leucovorin Protein Kinases Antineoplastic Combined Chemotherapy Protocols Humans Datasets as Topic Neoplasm Recurrence, Local Machine Learning Fluorouracil Organoplatinum Compounds Prognosis Cell Cycle Proteins Colorectal Neoplasms Biomarkers, Tumor
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Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.

AJNR. American journal of neuroradiology Nov 14, 2019
BACKGROUND AND PURPOSE: Limbic encephalitis is an autoimmune disease. A variety of autoantibodies have been associated with different subtypes of limbic encephalitis, whereas its MR imaging signature is uniformly characterized by mesiotemporal abnorm...
Autoantibodies Glutamate Decarboxylase Intracellular Signaling Peptides and Proteins Autoantigens Female Limbic Encephalitis Neuroimaging Humans Adult Machine Learning Male Brain Middle Aged Retrospective Studies Magnetic Resonance Imaging
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