Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes.

Journal: Journal of neurointerventional surgery
PMID: 31685695

Abstract

BACKGROUND AND AIMS: Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS emboli and to assess associations between their expression levels and clinical and procedural information.

Authors

  • Andrew Douglas
    CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Seán Fitzgerald
    CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Oana Madalina Mereuta
    CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Rosanna Rossi
    CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Sean O'Leary
    CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Abhay Pandit
    CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Ray McCarthy
    Cerenovus, Ballybrit, Galway, Ireland.
  • Michael Gilvarry
    Cerenovus, Ballybrit, Galway, Ireland.
  • Lukas Holmegaard
    Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Margareta Abrahamsson
    Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Mikael Jerndal
    Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Niclas Dehlfors
    Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Paul Brennan
    Neurointerventional Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  • Sarah Power
    Interventional Neuroradiology Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  • Alan O'Hare
    Neurointerventional Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  • Emma Griffin
    Interventional Neuroradiology Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  • David F Kallmes
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Waleed Brinjikji
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America.
  • István Szikora
    Department of Neurointerventions, National Institute of Neurosciences, Budapest, Hungary.
  • Turgut Tatlisumak
    Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Alexandros Rentzos
    Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • John Thornton
    Neurointerventional Service, Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  • Karen Doyle
    CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland karen.doyle@nuigalway.ie.

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