AIMC Topic: Blood Platelets
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Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.
Nature communications
May 15, 2025
Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditiona...
Multiscale simulations that incorporate patient-specific neural network models of platelet calcium signaling predict diverse thrombotic outcomes under flow.
PLoS computational biology
May 6, 2025
During thrombosis, platelets rapidly deposit and activate on the vessel wall, driving conditions such as myocardial infarction and stroke. The complexity of thrombus formation in pathological flow geometries, along with patient-specific pharmacologic...
Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.
Diabetologia
Apr 30, 2025
AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes ...
Tumor-educated platelets in lung cancer.
Clinica chimica acta; international journal of clinical chemistry
Apr 12, 2025
Non-invasive diagnostic monitoring techniques have become essential for treating lung cancer (LC), which continues to be the primary cause of cancer-related death worldwide. The new diagnostic biomarkers called tumour-educated platelets (TEPs) show s...
Development and Validation of Machine Learning Model Platelet Index-based Predictor for Colorectal Cancer Stage.
Asian Pacific journal of cancer prevention : APJCP
Dec 1, 2024
INTRODUCTION: Colorectal cancer (CRC) staging is essential for effective treatment planning and prognosis. While platelet indices have shown promise in indicating CRC aggressiveness, a platelet index-based predictor for CRC staging has not been estab...
Structured adaptive boosting trees for detection of multicellular aggregates in fluorescence intravital microscopy.
Microvascular research
Aug 13, 2024
Fluorescence intravital microscopy captures large data sets of dynamic multicellular interactions within various organs such as the lungs, liver, and brain of living subjects. In medical imaging, edge detection is used to accurately identify and deli...
Identification of Active Molecules against Thrombocytopenia through Machine Learning.
Journal of chemical information and modeling
Aug 7, 2024
Thrombocytopenia, which is associated with thrombopoietin (TPO) deficiency, presents very limited treatment options and can lead to life-threatening complications. Discovering new therapeutic agents against thrombocytopenia has proven to be a challen...
Establishing reflex test rules for platelet fluorescent counting method using machine learning models on Sysmex XN-series hematology analyzer.
International journal of laboratory hematology
Aug 5, 2024
INTRODUCTION: The platelet fluorescent counting (PLT-F) method is utilized as a reflex test method following the initial test of the platelet impedance counting (PLT-I) method in clinical practice on the Sysmex XN-series automated hematology analyzer...
Evaluation of artificial intelligence-assisted morphological analysis for platelet count estimation.
International journal of laboratory hematology
Jul 20, 2024
INTRODUCTION: This study aims to assess the performance of the platelet count estimation using artificial intelligence technology on the MC-80 digital morphology analyzer.
Improving platelet-RNA-based diagnostics: a comparative analysis of machine learning models for cancer detection and multiclass classification.
Molecular oncology
Jun 17, 2024
Liquid biopsy demonstrates excellent potential in patient management by providing a minimally invasive and cost-effective approach to detecting and monitoring cancer, even at its early stages. Due to the complexity of liquid biopsy data, machine-lear...
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