AIMC Topic: von Willebrand Factor

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Multimodal learning for mapping genotype-phenotype dynamics.

Nature computational science Jan 28, 2025
How complex phenotypes emerge from intricate gene expression patterns is a fundamental question in biology. Integrating high-content genotyping approaches such as single-cell RNA sequencing and advanced learning methods such as language models offers...
Humans Machine Learning Transcriptome Single-Cell Analysis Genotype Phenotype Gene Expression Profiling Genetic Association Studies Computational Biology von Willebrand Factor
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Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes.

Journal of neurointerventional surgery Nov 4, 2019
BACKGROUND AND AIMS: Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS emboli and to assess associ...
Cerebral Revascularization von Willebrand Factor Thromboembolism Male Treatment Outcome Brain Ischemia Blood Platelets Stroke Machine Learning Female Humans
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Prediction of Sub-Monomer A2 Domain Dynamics of the von Willebrand Factor by Machine Learning Algorithm and Coarse-Grained Molecular Dynamics Simulation.

Scientific reports Jun 21, 2019
We develop a machine learning tool useful for predicting the instantaneous dynamical state of sub-monomer features within long linear polymer chains, as well as extracting the dominant macromolecular motions associated with sub-monomer behaviors of i...
Protein Conformation Humans Machine Learning Molecular Dynamics Simulation Algorithms von Willebrand Factor
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Presentation and diagnosis of patients with type 3 von Willebrand disease in resources-limited laboratory.

Hematology/oncology and stem cell therapy Jul 3, 2018
Von Willebrand disease (VWD) is a bleeding disorder that results from decreased von Willebrand factor (VWF) activity <0.30 iu/mL. Therefore, the diagnosis of type 3 VWD in patients with bleeding requires finding a VWF:Ag and/or VWF:platelet ristoceti...
Male Bleeding Time Infant, Newborn Infant Adult von Willebrand Disease, Type 3 Humans Cohort Studies von Willebrand Factor Child Female Child, Preschool Adolescent Blood Coagulation Tests
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Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus.

Journal of diabetes research Dec 6, 2015
This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (album...
Adolescent Diabetic Nephropathies Renal Insufficiency, Chronic Albuminuria Diabetes Mellitus, Type 1 Tumor Necrosis Factor-alpha Adult Interferon-gamma Male Interleukin-6 Fibrin Fibrinogen Degradation Products Middle Aged Female Biomarkers ADAMTS13 Protein Humans ADAM Proteins Interleukin-10 Young Adult von Willebrand Factor
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Evaluation of risk factors for thromboembolic events in multiple myeloma patients using multiple machine learning models.

Medicine Feb 14, 2025
Venous thromboembolic events (VTE) is a frequent complication in multiple myeloma (MM) patients, raising mortality. This study aims to use machine learning to identify VTE risk factors in MM, helping to pinpoint high-risk individuals for better clini...
Risk Assessment Venous Thrombosis C-Reactive Protein Male Retrospective Studies Middle Aged Female Multiple Myeloma Aged von Willebrand Factor Adult Fibrinogen Humans Factor VIII Risk Factors Venous Thromboembolism Machine Learning
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