DeepMF: deciphering the latent patterns in omics profiles with a deep learning method.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: With recent advances in high-throughput technologies, matrix factorization techniques are increasingly being utilized for mapping quantitative omics profiling matrix data into low-dimensional embedding space, in the hope of uncovering insights in the underlying biological processes. Nevertheless, current matrix factorization tools fall short in handling noisy data and missing entries, both deficiencies that are often found in real-life data.

Authors

  • Lingxi Chen
    Department of Computer Science, City University of Hong Kong, Hong Kong 99907, China.
  • Jiao Xu
    City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, Hong Kong, China.
  • Shuai Cheng Li
    Department of Computer Science, City University of Hong Kong, Hong Kong, Hong Kong SAR, China.