Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections.

Journal: PloS one
PMID: 32628701

Abstract

OBJECTIVE: Current urinary tract infection (UTI) diagnostic strategies that rely on leukocyte esterase have limited accuracy. We performed an aptamer-based proteomics pilot study to identify urine protein levels that could differentiate a culture proven UTI from culture negative samples, regardless of pyuria status.

Authors

  • Liang Dong
    School of Computer Science and Technology, Henan Polytechnic University, Jiaozuo, China.
  • Joshua Watson
    Division of Infectious Disease, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  • Sha Cao
    Computational Systems Biology Lab, Department of Biochemistry and Molecular Biology, and Institute of Bioinformatics, University of Georgia, GA 30602, USA.
  • Samuel Arregui
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, United States of America.
  • Vijay Saxena
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, United States of America.
  • John Ketz
    The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  • Abduselam K Awol
    Earlham College, Richmond, Indiana, United States of America.
  • Daniel M Cohen
    Division of Emergency Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  • Jeffrey M Caterino
    Division of Emergency Medicine, The Ohio State University, Columbus, Ohio, United States of America.
  • David S Hains
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, United States of America.
  • Andrew L Schwaderer
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, United States of America.

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