An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy.

Journal: Scientific reports
Published Date:

Abstract

We present a comprehensive analysis of the submissions to the first edition of the Endoscopy Artefact Detection challenge (EAD). Using crowd-sourcing, this initiative is a step towards understanding the limitations of existing state-of-the-art computer vision methods applied to endoscopy and promoting the development of new approaches suitable for clinical translation. Endoscopy is a routine imaging technique for the detection, diagnosis and treatment of diseases in hollow-organs; the esophagus, stomach, colon, uterus and the bladder. However the nature of these organs prevent imaged tissues to be free of imaging artefacts such as bubbles, pixel saturation, organ specularity and debris, all of which pose substantial challenges for any quantitative analysis. Consequently, the potential for improved clinical outcomes through quantitative assessment of abnormal mucosal surface observed in endoscopy videos is presently not realized accurately. The EAD challenge promotes awareness of and addresses this key bottleneck problem by investigating methods that can accurately classify, localize and segment artefacts in endoscopy frames as critical prerequisite tasks. Using a diverse curated multi-institutional, multi-modality, multi-organ dataset of video frames, the accuracy and performance of 23 algorithms were objectively ranked for artefact detection and segmentation. The ability of methods to generalize to unseen datasets was also evaluated. The best performing methods (top 15%) propose deep learning strategies to reconcile variabilities in artefact appearance with respect to size, modality, occurrence and organ type. However, no single method outperformed across all tasks. Detailed analyses reveal the shortcomings of current training strategies and highlight the need for developing new optimal metrics to accurately quantify the clinical applicability of methods.

Authors

  • Sharib Ali
    Institute of Biomedical Engineering, Big Data Institute, Department of Engineering Science, University of Oxford, Oxford, UK. sharib.ali@eng.ox.ac.uk.
  • Felix Zhou
    Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
  • Barbara Braden
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Adam Bailey
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Suhui Yang
    Ping An Technology (Shenzhen) Co. Ltd, Shenzhen, China.
  • Guanju Cheng
    Ping An Technology (Shenzhen) Co. Ltd, Shenzhen, China.
  • Pengyi Zhang
  • Xiaoqiong Li
    Beijing Institute of Technology, Beijing, China.
  • Maxime Kayser
    Technishe Universität München, Munich, Germany.
  • Roger D Soberanis-Mukul
    Technishe Universität München, Munich, Germany.
  • Shadi Albarqouni
  • Xiaokang Wang
    Department of Biomedical Engineering, University of California, Davis, USA.
  • Chunqing Wang
    Department of Ultrasound Imaging, Tiantan Hospital, Beijing, China.
  • Seiryo Watanabe
    Department of Bioinformatic Engineering, Osaka University.
  • İlkay Öksüz
    İstanbul Technical University Faculty of Engineering, Department of Computer Engineering, İstanbul, Türkiye.
  • Qingtian Ning
    Department of Automation, Shanghai Jiao Tong University, Shanghai, China.
  • Shufan Yang
    School of Engineering, University of Glasgow, Glasgow, UK.
  • Mohammad Azam Khan
  • Xiaohong W Gao
    Department of Computer Science , Middlesex University , London NW4 4BT , U.K.
  • Stefano Realdon
    Instituto Onclologico Veneto, IOV-IRCCS, Padova, Italy.
  • Maxim Loshchenov
    A.M. Prokhorov General Physics Institute, Russian Academy of Science, Moscow, Russia.
  • Julia A Schnabel
    Division of Imaging Sciences and Biomedical Engineering, King's College London, UK.
  • James E East
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Georges Wagnieres
    Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland.
  • Victor B Loschenov
    A.M. Prokhorov General Physics Institute, Russian Academy of Science, Moscow, Russia.
  • Enrico Grisan
    Department of Information Engineering, University of Padova, Padova, Italy.
  • Christian Daul
    CRAN UMR 7039, University of Lorraine, CNRS, Nancy, France.
  • Walter Blondel
    CRAN UMR 7039, University of Lorraine, CNRS, Nancy, France.
  • Jens Rittscher
    Department of Engineering Science, University of Oxford, Oxford, United Kingdom.